Nucleoporin



Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD). The images at the left and at the right correspond to one representative Nucleoporin structure, i.e. crystal structure of yeast Nucleoporin NUP159 from Saccharomyces cerevisiae (1xip),

NUP2
3n7c – NUP2 RANBD – Ashbya gossypii

2c1t – yNUP2 N-terminal+importrin alpha subunit - yeast

NUP35
1wwh – mNUP35 MPPN domain - mouse

NUP50
2ec1 – hNUP50 RANBD - human

2c1m – mNUP50 N-terminal+importin

NUP53
3p3d - NUP53 RRM domain - Pischia guillermondii

NUP58
2osz – rNUP58/45 - rat

NUP84
3jro, 3iko – yNUP84+NUP145+protein Sec13

NUP85
3f3f, 3f3g, 3f3p, 3ewe – yNUP85+Seh1

NUP98
3mmy – hNUP98 fragment+mRNA export factor

2q5x, 2q5y – hNUP98 C-terminal

1ko6 – hNUP98 C-terminal

NUP100
3nf5 – NUP100 C-terminal – Candida glabrata

NUP107
3i4r, 3cqc, 3cqg – hNUP107+NUP133

NUP116
2aiv – yNUP116 C-terminal - NMR

NUP120
3f7f, 3h7n, 3hxr – yNUP120

NUP133
1xks – hNUP133 N-terminal

3kfo – yNUP133 C-terminal

NUP145
3bg0, 3bg1 – hNUP145+Sec13-related protein

3kep, 3kes – yNUP145 autoproteolytic domain

3jrp - yNUP145+protein Sec13

NUP153
3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8, 3ch5 – hNUP153+RAN

2ebq, 2ebr, 2ebv, 2gqe - hNUP153 RANBD – NMR

2k0c – rNUP153 RANBD – NMR

NUP159
1xip – yNUP159 N-terminal

NUP170
3i5p, 3i5q – yNUP170

NUP214
3fmo, 3fmp, 3fhc – hNUP214+dead-box helicase

2oit – hNUP214 N-terminal

NUP358
1z5s – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN C-terminal

1xke - hNUP358 RANBD - NMR

NUP1P
2bpt – yNUP1P+importin β subunit

NUP2P
1un0 – yNUP2P N-terminal+importrin α subunit

NUP-NSP1
1o6o – yNUP-NSP1 residues 497-608+importrin β subunit

NUP-CDC31
2doq, 2gv5 – yNUP-CDC31+SFI1P

3fwb, 3fwc - yNUP-CDC31+SAC3

2rfo, 2qx5 – yNic96

1gyb – NUP+yNTF2